LRRK2 and Parkinson disease: Of the PPMI participants with a clinical diagnosis of PD, 88% wereS+ including 100% of SNCA PD, 93% of sporadicPD and GBA PD, 64% of LRRK2 PD, and 33% of PRKN PD.Most of the S- were among HC and non-manifesting genetic cohorts, including 182LRRK2 non-manifesting carriers and 170GBA non-manifesting carriers.