These CNs were defined based on their overall cellular composition and classified as Vasculature, Immune Warm and Cold Parenchyma, Bulk Tumor, MDSCs, PD-L1/PD-1, HLA-A, CD44 Immune, Proliferating, Inflammation, SMAs, and Undefined CNs (Fig. 5a). This evidence concerns the gene PDCD1 and neoplasm.