Within the 5-year deceased cohort, there was significant enrichment (P < 0.05) of cell-to-cell contact between PD-1+ Memory Helper T cells and Tumor cells, Neutrophils, Proliferating cells, CD44+ cells, HLA-A+ cells, MDSCs, and Macrophages (Fig. 4c). This evidence concerns the gene PDCD1 and neoplasm.