SHBG and type 2 diabetes mellitus: In the T2D application, higher risk correlated with higher body mass index and waist-to-hip ratio (Belkina and Denis 2010; Burhans et al. 2018), lower levels of sex hormone-binding globulin (SHBG) (Huang et al. 2023), and an imbalance in cholesterol levels (Lewis and Steiner 1996; Sparks et al. 2012; Vergès 2015)—that is, higher LDL and lower HDL (Supplemental Fig. A6).