Gcm2 has a crucial role in controlling the development of parathyroid glands, as it is necessary for differentiation and survival.[24, 25, 26] Mice lacking Gcm2 did not develop parathyroid glands and exhibited signs of hypoparathyroidism.[27] Simultaneously, Gcm2 attaches to the CaSR promoter and triggers the activation of the CaSR gene, thereby facilitating the development of parathyroid glands.[28] The results of our study demonstrated the presence of Gcm2 and CasR in parathyroid organoids, as evidenced by both morphological (Figure 3A) and molecular (Figure 4E) analysis. This evidence concerns the gene GCM2 and hypoparathyroidism.