CASR and hypoparathyroidism: Gcm2 has a crucial role in controlling the development of parathyroid glands, as it is necessary for differentiation and survival.[24, 25, 26] Mice lacking Gcm2 did not develop parathyroid glands and exhibited signs of hypoparathyroidism.[27] Simultaneously, Gcm2 attaches to the CaSR promoter and triggers the activation of the CaSR gene, thereby facilitating the development of parathyroid glands.[28] The results of our study demonstrated the presence of Gcm2 and CasR in parathyroid organoids, as evidenced by both morphological (Figure 3A) and molecular (Figure 4E) analysis.