Due to the important effects of suppressing the inflammatory and angiogenesis process, anti-VEGF agents are widely used to treat various kinds of retinal diseases nowadays.[8] Though the actual etiology of IRVAN syndrome has not been proved, the presentations of the disease are mainly by inflammation of the retinal vessels and the nonperfusion of the retina, which might be the indication of intravitreal anti-VEGF agent injection. This evidence concerns the gene VEGFA and IRVAN syndrome.