Studies have shown that IRT5 probiotics can alleviate dry eye symptoms, aligning with previous findings.[26,27] Recent research reveals that Lactobacillus plantarum NK151 and Bifidobacterium bifidum NK175 reduce dry eye symptoms by reshaping the gut microbiota and balancing anti-inflammatory and pro-inflammatory cytokines.[28] Kawashima et al[29] found that dietary supplements containing Enterococcus faecium WB2000 combined with lactoferrin improved dry eye symptoms, while Connell et al[30] demonstrated that oral lactoferrin maintained tear secretion in a dry eye mouse model. This evidence concerns the gene LTF and Keratoconjunctivitis sicca.