SQSTM1 and Alzheimer disease: However, in these disease states, the function of autophagy is often inhibited.[10,61] The strong correlation between autophagy and AD is evident from the observation of a significantly expanded autophagy compartment in patients with AD.[62] Further analysis of multilayer brain tissue proteins in patients at different stages of AD revealed accumulation of the autophagic substrate Sequestosome 1, indirectly suggesting a reduction in autophagy flux: a finding similar to that observed in an AD laboratory model.[63]