SLC5A2 and Alzheimer disease: Recent studies have demonstrated the presence of sodium-glucose cotransporters (SGLTs) in the mammalian nervous system, with SGLT2 being highly expressed in the hippocampus, cerebellum, and BBB endothelial cells.[24–28] This specific distribution pattern provides compelling scientific evidence for the protective role of DAPA in the nervous system.[9] Significantly, a recent large cohort study revealed that DAPA reduced the risk of dementia,[29] including one of its leading causes: AD.