NFE2L2 and neurodegenerative disease: In neurodegenerative diseases, the expression level of oxidative stress products is inversely proportional to the level of the nuclear factor erythroid 2-related factor (Nrf2) but directly proportional to the severity of the disease.[42] Recent studies have demonstrated that in AD model rats treated with lipopolysaccharide, there was a 73.17% decrease in the oxidative stress product malondialdehyde and a 67.57% decrease in Nrf2 content compared to control rats.