A positive association was observed between HOXB13 methylation and tumor grade, as well as microvessel invasion.[70] Another study revealed that HOXB13 mRNA exhibits almost no expression in both ccRCC and renal tissue which plays a critical role in the pathogenesis and progression of RCC.[71] This study also revealed that HOXB13 has significant connections with various targets involved in RCC, particularly within the Wnt pathway. Here, HOXB13 is linked to neoplasm.