It is primarily synthesized in the liver and serves as a key player in responding to infections, potential injuries, and malignancies.[46,47] It plays a crucial role in recruiting different types of leukocytes within the tumor immune microenvironment.[48] A recent study done on RCC samples has shown that expression levels of SAA1 were significantly higher in RCC tissues compared with normal tissues. Here, SAA1 is linked to renal cell carcinoma.