Additionally, the statistical model was able to predict the 5-year survival with an AUC of 0.7211 and 0.715 for the TCGA-ccRCC cohort and JAPAN-KIRC cohorts, respectively.[38] In a study by Li et al, ZIC2 was included in the proposed prognostic model, alongside 14 other genes including CCDC137, KL, FBXO3, CDC7, IL20RB, CDCA3, ANAPC5, OTOF, POFUT2, ATP13A1, MC1R, BRD9, ARFGAP1, and COL7A1. This evidence concerns the gene FBXO3 and nonpapillary renal cell carcinoma.