It is primarily synthesized in the liver and serves as a key player in responding to infections, potential injuries, and malignancies.[46,47] It plays a crucial role in recruiting different types of leukocytes within the tumor immune microenvironment.[48] A recent study done on RCC samples has shown that expression levels of SAA1 were significantly higher in RCC tissues compared with normal tissues. The gene discussed is SAA1; the disease is infection.