HIF1A and neoplasm: Furthermore, pH-responsive release of the EPIRUBICIN by core-shell M@Pt-MOF/EPI nano-platforms and reduction of EPI toxicity in off-target tissues are the potential advantage of the core-shell M@Pt-MOF/EPI nano-platforms, which ultimately resulted in a significant reduction of TNFB tumor size through overexpression of HIF-1α and Caspase-3 mRNA to overcome tumor hypoxia and induce apoptosis, respectively.