Antiphospholipid syndrome (APS) is an acquired autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPLA) such as IgG/IgM anticardiolipin (aCL), anti-β2-glycoprotein I antibodies (aβ2GPI), or lupus anticoagulant (LA). The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.