A growing number of studies have revealed a significant correlation and crosstalk between PANoptosis and metabolism.[29,30,42–44] For instance, abnormality of intracellular lipid metabolism can cause alterations of endoplasmic reticulum homeostasis, which in turn promotes tumor progression by suppressing apoptosis.[30,33,43] Additionally, mitochondrial oxidative stress could promote cellular pyroptosis by promoting CASP1-mediated cleavage of GSDMD.[43] In turn, activated GSDMD could further exacerbate mitochondrial dysfunction by forming pores in the mitochondrial membrane. The gene discussed is GSDMD; the disease is neoplasm.