Xu M et al[59] further found that ferroptosis promotes ulcerative colitis through endoplasmic reticulum stress-mediated death of intestinal epithelial cells and that GSK414, an inhibitor of PERK, can inhibit endoplasmic reticulum stress-mediated intestinal epithelial cell ferroptosis to alleviate ulcerative colitis. This evidence concerns the gene EIF2AK3 and ulcerative colitis.