GPX4 and osteoarthritis: Miao Y et al[123] found that 55 patients with osteoarthritis had elevated levels of iron ions in the synovial fluid and significantly reduced levels of SLC3A2 and GPX4 in cartilage, and that down-regulation of GPX4 increased cartilage cell sensitivity to oxidative stress, up-regulated cartilage catabolism-related proteins, such as MMP3 and matrix metalloproteinase 13, and promoted the degradation of chondrocytes extracellular matrix through the MAPK/NF-κB pathway, while Fer-1 and deferoxamine can delay the process of osteoarthritis.