After adjusting age, gender, race, education level, marital status, drinking status, physical activity, diabetes, dyslipidemia, hypertension, cancer, CVD, ACEI, diuretic, total energy intake, protein, calcium, HGB, ALP, uric acid, and CKD stage, we found that lower intake of riboflavin had a significant relationship with the higher risk of all-cause mortality (Q1: HR = 1.33, 95% CI: 1.05–1.69) (Table 2). The gene discussed is CYGB; the disease is metabolic syndrome.