CD8A and neoplasm: As anticipated, the activation of CD4+ and CD8+ T cells, which possess the ability to recognize pMHCII are inhibited by LAG-3 when APCs secrete a substantial quantity of pMHCII.[34] This procedure functions similarly to the immune evasion mechanism observed in tumor tissue.[36,37] Further investigation is needed to understand the intracellular signal transmitting mechanism after their combination.