LAG3 and melanoma: They also play a crucial role in the transmission and clearance of glycoproteins.[45,46] Early research has indicated that the binding of LESCtin to LAG-3 facilitates tumor escape by suppressing the function of T cells in melanoma.[46] Recent research has revealed that lymphocytes in the TME secrete LESCtin at extremely low levels, thereby indicating minimal impact of this ligand.[47] The precise role of this factor in different types of cancer remains uncertain.