GH may contribute to insulin resistance by boosting free fatty acid (FFA) production, which inhibits glucose transporter proteins in adipose tissue cells.[14] IGF-1 and insulin have a reciprocal relationship: IGF-1 boosts insulin sensitivity and secretion, whereas insulin promotes IGF-1 secretion by augmenting hepatic GH receptor (GHR) responsiveness. Here, GHR is linked to Insulin resistance.