The release of sCD40L into the circulation has been shown to be associated with the activation of the immune system and the development of atherosclerosis, which is a major risk factor for ACS.[2] Recent studies have suggested that sCD40L may be a useful prognostic factor for ACS, patients with high levels of sCD40L had a higher risk of death, myocardial infarction, and revascularization compared to those with low levels of sCD40L.[1] However, data from literature are conflicting, and the prognostic value of sCD40L in patients with ACS remains uncertain. The gene discussed is CD40LG; the disease is atherosclerosis.