CD40LG and acute coronary syndrome: It interacts with various cells involved in vascular function, such as endothelial cells, macrophages, and T cells, and plays a role in the fundamental mechanisms of inflammation, atherosclerosis, and thrombosis.[2] In terms of atherosclerosis and acute coronary syndrome (ACS), sCD40L has been found to contribute to the development, instability, and rupture of atherosclerotic plaques through different means.