It interacts with various cells involved in vascular function, such as endothelial cells, macrophages, and T cells, and plays a role in the fundamental mechanisms of inflammation, atherosclerosis, and thrombosis.[2] In terms of atherosclerosis and acute coronary syndrome (ACS), sCD40L has been found to contribute to the development, instability, and rupture of atherosclerotic plaques through different means. This evidence concerns the gene CD40LG and atherosclerosis.