In the study by DPhil and colleagues, a cohort of 265 sepsis patients and 106 controls was analyzed to map eQTLs, shedding light on the genetic intricacies of sepsis.[30] Among the findings, the IER3 was identified as a regulatory genetic variant, emphasizing its potential role in sepsis response.[30] This association not only highlights the complex genetic landscape of sepsis but also suggests potential avenues for therapeutic exploration. Here, IER3 is linked to Sepsis.