HIF1A and Sepsis: It’s been documented that, in the context of sepsis, hampering glycolysis results in neutrophil immunosuppression.[37] This phenomenon may be steered by the PI3K/Akt-HIF-1α pathway-mediated LDHA downregulation.[37] A notable contribution by Sadiku et al[38] highlights that neutrophils capitalize on the glycogen cycle for essential energy production, a critical determinant for their function and survival.