Taken together, our results show that Tdrd6M/M mice carrying p.Gly615X variant of Tdrd6 (equivalent to the p.Gly609X variant of TDRD6 identified in the patient) generated no TDRD6 protein and showed male infertility with round spermatid arrest, indicating this variant will completely disrupt the expression and function of TDRD6. The gene discussed is TDRD6; the disease is male infertility.