Among these pathways, the PI3K/Akt signaling pathway, HIF-1 signaling pathway, Janus kinase/signal transducer and activator of transcription (JAK-STAT) signaling pathway, and Prolactin signaling pathway are known to be closely related to MI and HF and are thus highlighted as key pathways of interest [36–38]. Here, PIK3CA is linked to hydrops fetalis.