PPARGC1A and ischemic stroke: It has been shown that brain microvascular endothelial cells undergo pyroptosis after ischemic stroke, and MDRN, as a peroxisome proliferator-activated receptor gamma coactivator 1-alpha activator, ameliorates pyroptosis and ischemic brain injury by reducing mitochondrial ROS via the peroxisome proliferator-activated receptor alpha/glutamate oxaloacetate transaminase 1 axis [47].