CXCR4 and colorectal carcinoma: This work reports the successful establishment of a CAM-PDX model derived from liver metastasis organoids from a CRC patient highly recapitulating the patient’s characteristics: The morphology, histopathology, and CXCR4 expression of the patient’s liver metastasis were reflected in in vitro PDOs and especially in CAM xenografts underlining the translational value of this alternative in vivo model for CRC patients.