Our results revealed that compared to the control group, RENT3B expression was upregulated in Medullary Breast Carcinoma, Ductal Breast Carcinoma, Cervical Cancer, Colorectal Cancer, Esophageal Squamous Cell Carcinoma, Gastric Cancer, Leukemia, Liver Cancer, Lung Cancer, Lymphoma, Other Cancer (Vulvar Intraepithelial Neoplasia, Embryonal Carcinoma, Mixed Germ Cell Tumor), Ovarian Serous Cystadenocarcinoma, Pancreatic Cancer, and Sarcoma. The gene discussed is UPF3B; the disease is esophageal squamous cell carcinoma.