Mutations in each of them cause severe neurological disorders (Ugur et al., 2020): chorea-acanthocytosis (VPS13A) (Rampoldi et al., 2001), Cohen syndrome (VPS13B) (Kolehmainen et al., 2003), Parkinson’s disease (VPS13C) (Lesage et al., 2016; Darvish et al., 2018; Schormair et al., 2018), and several neurological disorders or embryonic lethality in the case of complete loss-of-function (VPS13D) (Gauthier et al., 2018; Seong et al., 2018; Koh et al., 2020). Here, VPS13B is linked to nervous system disorder.