Figure 6 shows the volcano plot of differentially expressed genes (Figure 6a,c) and gene set enrichment analysis (GSEA) (Subramanian et al., 2005) (Figure 6b,d) of tumour‐derived macrophages exposed to MEK1‐hi versus MEK1‐low EVs in vitro (Figure 6a,b) or in vivo (Figure 6c,d). The gene discussed is MAP2K1; the disease is neoplasm.