No licensed/commercial schistosomiasis vaccine is currently available on the market against any Schistosoma parasite, but there have been some promising results in clinical trials, and currently there are four major leading human-based schistosomiasis vaccines that are undergoing clinical trials at various development phases: Sm-p80, Sm-TSP-2, Sh28GST, and Sm-14 [59]. This evidence concerns the gene THBS2 and schistosomiasis.