A normal PCT (cut-off: 0.5 μg/L using the BRAHMS PCTTM test) provides a strong negative predictive value for sepsis: procalcitonin-guided decision-making resulted in being superior to standard care in reducing antibiotic therapy in neonates born after 34 weeks of gestational age with suspected EOS in a multicenter randomized controlled trial (NeoPIns) [72]. This evidence concerns the gene CALCA and Sepsis.