TNF and obesity due to melanocortin 4 receptor deficiency: Similarly, as mentioned by Rahman et al. (2020), decreased TNF-α, IL-1β, and IL-6 expressions were shown in dogs fed tea polyphenols and a high-fat diet after 12 weeks, and TPs suppressed COX-2 and iNOS expression levels, diminishing obesity, liver inflammation, liver fat content, and degeneration [66].