Collagen-based hybrid biomaterials containing silver NPs, with sizes 30 to 50 nm, are synthesized.Anti-inflammatory efficiency of the biomaterials is evaluated measuring the secretion of pro-inflammatory cytokines, IL-6, IL-1β, and TNF-α.A significant reduction in the secretion of these cytokines are observed, which is attributed to the presence of silver NPs.Results indicate these hybrid scaffolds are strong anti-inflammatory agents, with potential applicability in periodontal disease treatment. Here, IL6 is linked to periodontal disorder.