Furthermore, using PPI network analysis, we found that Gstm1, Gstm3, Cyp3a11, cytochrome P450 2C55 (Cyp2c55), and Cyp21a1 had high connectivity with other genes, underscoring their significance in SW033291-ameliorated T2DM (Figure 4C). Here, GSTM1 is linked to type 2 diabetes mellitus.