GSTM1 and type 2 diabetes mellitus: The integration of transcriptomics and metabolomics in our study showed reduced hepatic levels of Gstm1 and Gstm3 in T2DM mice, but their levels increased after treatment with SW033291, indicating that SW033291 may up-regulate the expression of Gstm1 and Gstm3 to improve oxidative stress, enhance antioxidant activity, and thereby ameliorate T2DM.