ESR1 and gestational diabetes: Loci showing GDM-predominant effects were mapped to genes linked to islet cells, central glucose homeostasis, steroidogenesis, and placental expression—these GDM-predominant effect loci include (GCKR, SPC25-G6PC2, PCSK1, ESR1, MTNR1B, NEDD1, CMIP, and MAP3K15), whereas the loci at CDKAL1, TCF7L2 and CCND2 involved T2DM predominant effects [96].