In contrast, JIA shows a distinct biomarker profile with cytokines like Interleukin-1 (IL-1), Interleukin-6 (IL-6), and Interleukin-18 (IL-18) playing a more significant role, particularly in systemic JIA, and with unique Human Leukocyte Antigen (HLA) associations depending on the subtype [7,8,9,10,11,12,13,14]. This evidence concerns the gene IL6 and juvenile idiopathic arthritis.