The top downregulated genes in BC were novel.1721 (retrotransposon gag protein), novel.1706 (plant transposase), novel.3210 (AdoHcyase, adenosylhomocysteinase), Zm00001eb201380 (phosphoenolpyruvate carboxykinase (ATP)) and Zm00001eb033760 (oligopeptide transporter 5). The gene discussed is AHCY; the disease is breast cancer.