In order to ascertain whether hyperglycemia could be involved in the loss of the capacity of apoC1 to inhibit CETP in people with T1D, we performed a prospective study in patients with uncontrolled T1D, aiming to determine whether a significant improvement of glycemic control could restore the inhibitory effect of apoC1 on CETP. The gene discussed is APOC1; the disease is type 1 diabetes mellitus.