Our machine learning results showed that the intermediates of gluconeogenesis and the citric acid cycle, such as glucose, fructose 6-phosphate, glyceraldehyde 3-phosphate, malic acid, and citric acid, were significantly decreased by liraglutide in both DIO mice and patients with T2DM, which may also contribute to increasing insulin sensitivity by mitigating pro-inflammatory responses and excessive oxidative flux in obesity and T2DM [38,40,41]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.