Additionally, pesticide, phthalate, ALK, and heavy metal exposure also showed an elevated risk of hypospadias (aOR = 1.17, 95% CI (1.04, 1.32), p = 0.008), (aOR = 1.91, 95% CI (1.16, 3.15), p = 0.01), (aOR = 2.02, 95% CI (1.06, 3.86), p = 0.03), (aOR = 1.12, 95% CI (1.06, 1.20), p = 0.0003), respectively. The gene discussed is ALK; the disease is hypospadias.