Thus, in CF, CFTR-dependent altered regulation of T-cell cytokine secretion leads to a shift toward a pro-inflammatory state and a predominant Th2 response with exaggerated immunoglobulin E (IgE) levels, peripheral eosinophilia, and pulmonary infiltrates, a predisposition for ABPA [31,34,36,37,38,39,40,41,42,43]. This evidence concerns the gene IGHE and Increased total eosinophil count.