As per the CFF consensus criteria, minimal diagnostic criteria for ABPA in CF patients require evidence of acute or subacute clinical deterioration not attributable to another etiology, total serum IgE level > 1200 ng/mL while off steroids, evidence of Af sensitization and of the following: (1) serum precipitins to Af; (2) demonstration of Af-specific IgG antibodies in vitro; or (3) new or recent abnormalities on pulmonary radiologic imaging, which do not respond to antibiotics and chest physiotherapy [24,74]. The gene discussed is IGHE; the disease is cystic fibrosis.