KL and atherosclerosis: In an observational study of patients diagnosed recurrent AMI with non-obstructed coronary artery (MINOCA), Ciliberti et al. [30] have demonstrated that these patients tend to have a more severe atherosclerosis progression, which has been shown to be associated with inflammation, and Klotho may have a critical role in reducing atherosclerotic plaque destabilization by inhibiting an activated inflammatory response, improving prognosis among high-risk cardiovascular populations eventually.