IL5 and Insulin resistance: On the other hand, the Sanz-Cánovas et al. literature review of 2022 [42] found that frailty is a related but independent entity in the evolution of diabetes; high levels of cytokines like TNFα, IL-1, IL-5, or IL-6 that are present in diabetic patients induce insulin resistance and mitochondrial dysfunction, which alter lipid peroxidation, generate lipid increase in muscle cells, and favor the development of frailty and sarcopenia.