On the other hand, the Sanz-Cánovas et al. literature review of 2022 [42] found that frailty is a related but independent entity in the evolution of diabetes; high levels of cytokines like TNFα, IL-1, IL-5, or IL-6 that are present in diabetic patients induce insulin resistance and mitochondrial dysfunction, which alter lipid peroxidation, generate lipid increase in muscle cells, and favor the development of frailty and sarcopenia. Here, TNF is linked to Insulin resistance.