The combination of Growth Differentiation Factor-15 (GDF-15), Interleukin-6 (IL-6), Lipocalin-2 (LCN-2), and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) provide a multi-faceted approach to the diagnosis and understanding of coronary artery disease (CAD), as each biomarker reflects distinct biological processes involved in the disease. The gene discussed is HAVCR2; the disease is coronary artery disorder.