Within this system, ACE is one of the key enzymes, catalyzes the conversion of inactive Angiotensin I (Ang I) into the potent vasoconstrictor Angiotensin II (Ang II), thereby deactivating the vasodilator bradykinin [3]; this highlights the effectiveness of ACE inhibitors as an important therapeutic approach for the treatment of hypertension. This evidence concerns the gene ACE and hypertensive disorder.