Four abnormally expressed metabolic enzymes, glutaminase (GLS), glutamate dehydrogenase 1 (GDH1), hexokinase 2 (HK2) and glucose-6-phosphate dehydrogenase (G6PD), which directly affect metabolites in certain pathways, were found to be downregulated by Chr-A in glioblastoma cells. This evidence concerns the gene HK2 and glioblastoma.