The test is considered positive if there is symptomatic hypoglycemia with concurrent inappropriately elevated levels of insulin (at least 3 μU/mL or 18 pmol/L), proinsulin (at least 5 pmol/L), C-peptide (at least 0.2 nmol/L), and suppressed serum beta-hydroxybutyrate (less than 2.7 mmol/L) in the absence of sulfonylurea in the plasma. The gene discussed is INS; the disease is Hypoglycemia.