KLK3 and cancer: Ravery et al. [44] demonstrated that TRUS-guided biopsies using either 10 or 12 cores (if total prostate volume was >50 mL) was associated with 6.6% higher cancer detection compared to the sextant biopsy method, especially in patients with a PSA level under 10 ng/mL and/or a prostate volume over 50 mL.