In a retrospective analysis of surgical specimens of patients treated for HCC, without preoperative treatment (n = 32), after preoperative TACE (n = 16), or after preoperative SIRT (n = 2), SIRT was associated with a significant increase in Tumor-Infiltrating Lymphocytes, CD4+ and CD8+ T cells, and Granzyme-B expression compared to TACE or no preoperative treatment [8]. Here, GZMB is linked to hepatocellular carcinoma.