EGFR and non-small cell lung carcinoma: Among the main reasons behind this attempt, apart from the preclinical hypothesis of a radiosensitizing effect of EGFR-TKIs, there is evidence to suggest that patients with locally advanced EGFR-mutant NSCLC have a better survival rate but inferior distant control, especially central nervous system (CNS) metastases vs. those with EGFR wild-type NSCLC [55].