IDH3A and astrocytoma (excluding glioblastoma): Grade 4 adult-type diffuse gliomas, which include both isocitrate dehydrogenase (IDH) mutant gr (grade) 4 astrocytoma and IDH-wilde-type (wt) glioblastoma (GBM) gr4 according to to the fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) criteria, as published in 2021 [1], one of the most frequent primary brain tumors, typically occur in individuals of advanced age, with an average age of 64 years [2].