SAV1 and neoplasm: The Hippo pathway components have tumour suppressive activity and are represented by LATS1/2 (large tumour suppressor kinase 1/2), MST1/2 (mammalian STE20-like protein kinase, (SAV1) Salvador homolog 1, and (MOB1) kinase activator 1A/BPM has been shown to be related to Hippo pathway dysregulation, involving YAP/TAZ oncoproteins and LATS1/2 tumour suppressors, through the activation of specific mechanisms: tumour initiation, progression, metastasis, and drug resistance [60].