Our findings showed that one of the main components of EPE is chebulagic acid, which possesses antioxidant activity [72], suggesting that EPE improves renal function in HFD-produced T2DM mice partly due to the antioxidant activity of its main constituent, chebulagic acid, and indirectly decreases lipid depots, and decreases pro-inflammatory cytokine including KIM-1 levels. The gene discussed is HAVCR1; the disease is type 2 diabetes mellitus.