The expression levels of NPLOC4 and HSPA1A in T2D and control groups in the integrated GEO dataset were highly significant from a statistical perspective (p value < 0.01); the intensities levels of PPARG and HSP90AB1 in T2D and control groups in GEO were statistically noteworthy (p value < 0.05). Here, NPLOC4 is linked to type 2 diabetes mellitus.