HDAC6 and cystic fibrosis: This work stems from previous research showing that CF cells and CF mice show reduced tubulin acetylation and an altered microtubule polymerization with multiple consequences including altered endosomal trafficking, increased perinuclear cholesterol accumulation and inflammatory NF-κB signaling [110,111,112,113,114], which were reversed by an inhibition of Hdac6 [110,113].