We observed significantly elevated concentrations of the proteins SEMA7A (Figure 1A), (p < 0.001), SEMA4D (Figure 1B), (p < 0.001), ADAM8 (Figure 1C), (p < 0.001), and ADAMTS10 (Figure 1D), (p < 0.05) in CRC tissues compared to margin tissues. This evidence concerns the gene ADAMTS10 and colorectal carcinoma.