Due to its significance in managing immune responses, SEMA7A is involved in the pathogenesis of various diseases: rheumatoid arthritis [65], multiple sclerosis [66], pulmonary fibrosis [67], liver fibrogenesis [68], and multiple types of cancer, including breast [69], pancreatic [70], CRC [71], gastric [72], melanoma, and oral squamous cell carcinoma [61]. Here, SEMA7A is linked to melanoma.